IL-12 p70
IL-12 is a potent regulator of cell-mediated immune responses and it induces IFN-γ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue-type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells, and induces the development of IFN-γ-producing Th1 cells. Recombinant Murine IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) and 40 kDa (p40) subunits (506 total amino acid residues) .
Product Specifications
Synonyms
NKSF, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor (CLMF), TSF
NCBI Gene ID
P35: 16159 p40: 16160
UniProt
P35: P43431 p40: P43432
Accession Number
NP_032377.1, NP_001290173.1
Accession Number mRNA
NM_008351.4, NM_001303244.1
Reactivity
Mouse
Cross Reactivity
Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses
Bioactivity
Length
506
Form
Lyophilized
Molecular Weight
75 kDa
Host or Source
CHO cells
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