IL-11
Interleukin 11 (IL-11), also known as adipogenesis inhibitory factor (AGIF), has multiple effects on both hematopoietic and nonhematopoietic cells. Many of the biological effects described for IL-11 overlap those for IL-6. IL-11 exerts its biological activities through binding to a specific high-affinity receptor complex consisting of an IL-11 receptor chain and gp130.
Product Specifications
Synonyms
IL11; AGIF; IL-11
NCBI Gene ID
3589
UniProt
P20809
Accession Number
NP_000632.1
Accession Number mRNA
NM_000641
Chromosomal Location
19q13.3-q13.4
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant mouse IL-11
Applications
ELISA, N, IHC
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Bioactivity
Immunostaining: This antibody stained human brain stroke (including control cortex and stroke core areas) tissue. The primary antibody was incubated at 2.5 µg/ml overnight at 4°C. This was followed by a fluorophore conjugated secondary antibody. Neutralization: To yield one-half of the maximal inhibition [ND50] of the biological activity of human IL-11 (5 ng/ml), a concentration of 2.4-3.6 µg/ml of this antibody is required.
Form
Lyophilized from PBS
Buffer
PBS
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C.
Host or Source
Mouse
Isotype
IgG2
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