IL-10 receptor beta
IL-10 mediates its biological activities via binding to a heteromeric complex of two distinct type II cytokine receptor subunits, the ligand binding subunit IL-10 R alpha (IL-10 R1) and the signal-transducing accessory subunit IL-10 R beta (IL-10 R2) . IL-10 R alpha is specific for IL-10 and expressed by most hemopoietic cells. IL-10 R beta is a widely expressed shared subunit for IL-10, IL-22, IL-26 and the IFNl proteins IL-28A, IL-28B and IL-29.
Product Specifications
Synonyms
IL10RB; CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2
NCBI Gene ID
3588
UniProt
Q08334
Accession Number
NP_000619.3
Accession Number mRNA
NM_000628.4
Chromosomal Location
21q22.1-q22.2; 21q22.11
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human IL-10 Rbeta EC domain
Clone
(#8R24)
Applications
WB, N
Purification Method
Protein A/G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG1
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