IL-10 receptor alpha

Human and mouse IL-10 receptors are structurally related to the IFN-gamma receptor. These receptors are members of the class II subgroup of the cytokine receptor superfamily. The deduced amino acid sequence of human IL-10 R is approximately 60% identical to mouse IL-10 R. Although human IL-10 has cross-species activities and is active on mouse cells, mouse IL-10 is species-specific in its actions and does not bind to the human IL-10 receptor. The human IL-10 R gene has been mapped to chromosome 11q23.3. Recombinant IL-10 soluble receptor, consisting of the extracellular domain of IL-10 R, binds IL-10 with high affinity in solution and is a potent IL-10 antagonist.

Product Specifications

Synonyms

IL10RA; CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1

NCBI Gene ID

3587

UniProt

Q13651

Accession Number

NP_001549.1

Accession Number mRNA

NM_001558.3

Chromosomal Location

11q23

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant human IL-10 Rbalpha EC domain

Clone

(#7Q35)

Applications

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.