IL-8 (77aa)

IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant human IL-8 (endothelial-derived) is an 8.9 kDa protein containing 77 amino acid residues.

Product Specifications

Synonyms

IL8; NAF; GCP1; LECT; LUCT; NAP1; CXCL8; GCP-1; LYNAP; MDNCF; MONAP; NAP-1

NCBI Gene ID

3576

UniProt

P10145

Accession Number

NP_000575.1

Accession Number mRNA

NM_000584.3

Chromosomal Location

4q13-q21

Reactivity

Human

Cross Reactivity

Chicken, Mouse, Human, Bacteria

Sequence

AVLPRSAKEL RCQCIKTYSK PFHPKFIKEL RVIESGPHCA NTEIIVKLSD GRELCLDPKE NWVQRVVEKF LKRAENS

Endotoxin

< 0.1 ng/µg of protein (< 1EU/µg)

Purity

> 98% by SDS-PAGE & HPLC analyses

Bioactivity

Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 25.0-150.0 ng/ml.

Length

Form

Lyophilized

Molecular Weight

8.9 kDa

Host or Source

E. coli

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