IL-8 (77aa)
IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant human IL-8 (endothelial-derived) is an 8.9 kDa protein containing 77 amino acid residues.
Product Specifications
Synonyms
IL8; NAF; GCP1; LECT; LUCT; NAP1; CXCL8; GCP-1; LYNAP; MDNCF; MONAP; NAP-1
NCBI Gene ID
3576
UniProt
P10145
Accession Number
NP_000575.1
Accession Number mRNA
NM_000584.3
Chromosomal Location
4q13-q21
Reactivity
Human
Cross Reactivity
Chicken, Mouse, Human, Bacteria
Sequence
AVLPRSAKEL RCQCIKTYSK PFHPKFIKEL RVIESGPHCA NTEIIVKLSD GRELCLDPKE NWVQRVVEKF LKRAENS
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 25.0-150.0 ng/ml.
Length
77
Form
Lyophilized
Molecular Weight
8.9 kDa
Host or Source
E. coli
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