IL-6
IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.
Product Specifications
Synonyms
IL6; HGF; HSF; BSF2; IL-6; IFNB2
NCBI Gene ID
3569
UniProt
P05231
Accession Number
NP_000579
Accession Number mRNA
NM_000600
Chromosomal Location
7p21
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human recombinant IL-6
Clone
(#1X45)
Applications
WB, IHC (F), N/B
Purification Method
Protein G chromatography
Assay Protocol
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG2
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