IL-6
IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein containing 187 amino acid residues.
Product Specifications
Synonyms
Il6; Il-6
NCBI Gene ID
16193
UniProt
P08505
Accession Number
NP_112445.1
Accession Number mRNA
NM_031168
Chromosomal Location
5 B1; 5 17.0 cM
Reactivity
Mouse
Cross Reactivity
Monkey, Mouse, Rat, Trout
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & Coomassie stain
Bioactivity
The ED50 as determined by the dose-dependent stimulation of murine hybridoma B9 cells is in the range of 5-20 pg/ml.
Length
188
Form
Lyophilized
Buffer
50 mM Acetic Acid
Reconstitution
50 mM Acetic Acid
Molecular Weight
21.7 kDa
Host or Source
E. coli
N Terminal Sequence
MFPTS
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