IL-4R alpha

Two types of IL-4 receptor complexes have been described. The typeI IL-4 receptor complex is composed of a high-affinity IL-4-binding subunit (referred to as IL-4 R or IL-4 R alpha) and the common gamma chain that does not bind IL-4 by itself. The type II IL-4 receptor complex is composed of IL-4 R and IL-13 R alpha 1. Besides IL-4 signals, the type II IL-4 receptor complex can also transduce IL-13 signals. In the type II complex, IL-4 R subunit binds only IL-4 and not IL-13. Similarly, the IL-13 R alpha 1 subunit binds only IL-13 and not IL-4.

Product Specifications

Synonyms

Il4ra; Il4r; CD124

NCBI Gene ID

3566

UniProt

P24394

Accession Number

NP_000409.1

Accession Number mRNA

NM_000418

Chromosomal Location

16p12.1-p11.2

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Human recombinant IL-4R alpha EC domain

Clone

(#4Y44)

Applications

WB, IHC (P), N

Purification Method

Protein G chromatography

Assay Protocol

Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.