IL-3 receptor alpha
Interleukin 3 (IL-3) is a pleiotropic cytokine that can stimulate proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. IL-3 exerts its activity through binding to a specific cell surface receptor known as IL-3 R. IL-3 R is a heterodimeric structure composed of a 70 kDa IL-3 R alpha subunit (CD123 or beta common) and a 120-140 kDa IL-3 R beta subunit (CD131) . CD131 also associates with the receptor for Erythropoietin, forming a tissue-protective hetero-receptor complex.
Product Specifications
Synonyms
Il3ra; CD123; SUT-1; CDw123
NCBI Gene ID
16188
UniProt
P26952
Accession Number
NP_032395.1
Accession Number mRNA
NM_008369.1
Chromosomal Location
14 A2; 14 1.5 cM
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant protein of the EC domain of IL-3 R alpha
Clone
(#9G52)
Applications
WB
Purification Method
Protein A/G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Rat
Isotype
IgG2
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