IL-3 receptor alpha

Interleukin 3 (IL-3) is a pleiotropic cytokine that can stimulate proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. IL-3 exerts its activity through binding to a specific cell surface receptor known as IL-3 R. IL-3 R is a heterodimeric structure composed of a 70 kDa IL-3 R alpha subunit (CD123 or beta common) and a 120-140 kDa IL-3 R beta subunit (CD131) . CD131 also associates with the receptor for Erythropoietin, forming a tissue-protective hetero-receptor complex.

Product Specifications

Synonyms

Il3ra; CD123; SUT-1; CDw123

NCBI Gene ID

16188

UniProt

P26952

Accession Number

NP_032395.1

Accession Number mRNA

NM_008369.1

Chromosomal Location

14 A2; 14 1.5 cM

Reactivity

Anti-Mouse

Cross Reactivity

Mouse

Target Antigen

Recombinant protein of the EC domain of IL-3 R alpha

Clone

(#9G52)

Applications

Purification Method

Protein A/G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.