IL-3 receptor alpha
Interleukin 3 (IL-3) is a pleiotropic cytokine that can stimulate proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. IL-3 exerts its activity through binding to a specific cell surface receptor known as IL-3 R. IL-3 R is a heterodimeric structure composed of a 70 kDa IL-3 R alpha subunit (CD123 or beta common) and a 120-140 kDa IL-3 R beta subunit (CD131) . CD131 also associates with the receptor for Erythropoietin, forming a tissue-protective hetero-receptor complex.
Product Specifications
Synonyms
IL-3 R alpha, IL3ra
NCBI Gene ID
3563
UniProt
P26951
Accession Number
NO_01254642.1
Accession Number mRNA
NM_001267713.1
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human IL-3 receptor alpha extracellular domain
Clone
(#11A23)
Applications
IHC, WB, N
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG1
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