IL-3
IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine. Recombinant murine IL-3 is a 15.1 kDa globular protein containing 135 amino acid residues.
Product Specifications
Synonyms
Il3; BPA; PSF; HCGF; Il-3; MCGF; Csfmu
NCBI Gene ID
16187
UniProt
P01586
Accession Number
NP_034686.2
Accession Number mRNA
NM_010556.4
Chromosomal Location
11 B1; 11 28.5 cM
Reactivity
Mouse
Cross Reactivity
Rat, Mouse, Human, Monkey, Bacteria, Gerbil
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & Coomassie stain
Bioactivity
The ED50 as determined by the dose-dependent stimulation of the proliferation of murine NFS-60 cells is in the range of 20-100 pg/ml.
Length
140
Form
Lyophilized
Buffer
PBS
Reconstitution
Water
Molecular Weight
15.8 kDa
Host or Source
E. coli
N Terminal Sequence
ASISGR
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