IL-1 R1

IL-1 receptor type I (IL1R-I) is an 80 kD transmembrane glycoprotein and a member of the immunoglobulin superfamily expressed on T cells, thymocytes, dendritic cells, fibroblasts, vascular endothelial cells, epithelial cells and neural cells. IL1R-I binds the mature forms of IL-1α, IL-1β, and IL-1Ra proteins. High affinity binding and signaling by the type I IL-1 receptor requires CD121a and the accessory protein, IL-1R AcP, which does not bind IL-1 alone, but forms a dimer capable of binding IL-1.

Product Specifications

Synonyms

Il1r1; IL-iR; CD121a; CD121b; Il1r-1; Interleukin 1 receptor 1

NCBI Gene ID

16177

UniProt

P13504

Accession Number

NP_032388.1

Accession Number mRNA

NM_008362.2

Chromosomal Location

1 B; 1 19.5 Cm

Reactivity

Anti-Mouse

Cross Reactivity

Mouse

Target Antigen

Extracellular domain of mouse IL1R-I

Clone

(#11B7)

Applications

Purification Method

Protein G/A chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -20°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.