IGF-BP5
IGF-BP5 is a member of the insulin-like growth factor binding protein (IGF-BP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Product Specifications
Synonyms
IGFBP5; IBP5
NCBI Gene ID
3488
UniProt
P24593
Accession Number
NP_000590.1
Accession Number mRNA
NM_000599
Chromosomal Location
2q33-q36
Reactivity
Human
Cross Reactivity
Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is ≤ 0.3 μg/ml in the presence of 15 ng/ml of human IGF-II.
Length
253
Form
Lyophilized
Molecular Weight
28.6 kDa
Host or Source
E. coli
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