IFN-lambda-1 (Animal Free)
IFN lambda-1, -2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and the interferons. All three IFN-lambdas use a distinct receptor system composed of an IFN-λR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14) . Signaling through this receptor system induces antiviral defenses similar to, but distinct from, that of type I interferons. Recombinant Human IFN-λ1 is a 19.8 kDa protein containing 178 amino acid residues.
Product Specifications
Synonyms
IL29; IFNL1; IL-29; IL-29, IL-28A; IL-28B
NCBI Gene ID
282618
UniProt
Q8IU54
Accession Number
NP_742152.1
Accession Number mRNA
NM_172140.1
Chromosomal Location
19q13.13
Reactivity
Human
Cross Reactivity
Human, Monkey
Sequence
PTSKPTTTGK GCHIGRFKSL SPQELASFKK ARDALEESLK LKNWSCSSPV FPGNWDLRLL QVRERPVALE AELALTLKVL EAAAGPALED VLDQPLHTLH HILSQLQACI QPQPTAGPRP RGRLHHWLHR LQEAPKKESA GCLEASVTFN LFRLLTRDLK YVADGNLCLR TSTHPEST
Endotoxin
< 0.01 ng/µg of protein (< 0.1 EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.2-0.5 ng/ml.
Length
178
Form
Lyophilized
Molecular Weight
19.8 kDa
Host or Source
E. coli
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