IFN-lambda-1 (Animal Free)

IFN lambda-1, -2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and the interferons. All three IFN-lambdas use a distinct receptor system composed of an IFN-λR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14) . Signaling through this receptor system induces antiviral defenses similar to, but distinct from, that of type I interferons. Recombinant Human IFN-λ1 is a 19.8 kDa protein containing 178 amino acid residues.

Product Specifications

Synonyms

IL29; IFNL1; IL-29; IL-29, IL-28A; IL-28B

NCBI Gene ID

282618

UniProt

Q8IU54

Accession Number

NP_742152.1

Accession Number mRNA

NM_172140.1

Chromosomal Location

19q13.13

Reactivity

Human

Cross Reactivity

Human, Monkey

Sequence

PTSKPTTTGK GCHIGRFKSL SPQELASFKK ARDALEESLK LKNWSCSSPV FPGNWDLRLL QVRERPVALE AELALTLKVL EAAAGPALED VLDQPLHTLH HILSQLQACI QPQPTAGPRP RGRLHHWLHR LQEAPKKESA GCLEASVTFN LFRLLTRDLK YVADGNLCLR TSTHPEST

Endotoxin

< 0.01 ng/µg of protein (< 0.1 EU/µg)

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Bioactivity

Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.2-0.5 ng/ml.