IFN-gamma (Animal Free)
IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells, and antigen-recognizing B and T lymphocytes, regulates the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions, including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ is species-specific and is biologically active only in human and primate cells. Recombinant Human IFN-γ is a 16.8 kDa protein containing 144 amino acid residues.
Product Specifications
Synonyms
IFNG; IFG; IFI
NCBI Gene ID
3458
UniProt
P01579
Accession Number
NP_000610.2
Accession Number mRNA
NM_000619
Chromosomal Location
12q14
Reactivity
Human
Cross Reactivity
Fish + Virus, Human, Human + Bacteria, Mandarin Fish, Monkey, Rat
Sequence
Endotoxin
< 0.01 ng/µg of protein (< 0.1 EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity
The ED50 determined by a cytotoxicity assay using HT-29 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
Length
144
Form
Lyophilized
Molecular Weight
16.8 kDa
Host or Source
E. coli
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