ICAM-1 (CD54)
ICAMs are members of the Ig superfamily of calcium-independent transmembrane glycoproteins. ICAM-1 is a ligand for lymphocyte function-associated (LFA) and Mac-1 integrins and the major human rhinovirus receptor. The primary function of ICAM-1 is to provide adhesion between endothelial cells and leukocytes after stress or injury. The human ICAM-1 gene codes for a 505 amino acid transmembrane glycoprotein containing a 29 amino acid cytoplasmic domain, a 23 amino acid transmembrane domain, and a 453 amino acid extracellular domain. Recombinant human ICAM-1 is a 49.5 kDa glycoprotein comprising the extracellular domain (453 amino acid residues) of ICAM-1. Monomeric glycosylated ICAM-1 migrates at an apparent molecular weight of approximately 72.0-80.0 kDa by SDS-PAGE analysis under reducing conditions.
Product Specifications
Synonyms
ICAM1; BB2; CD54; P3.58
NCBI Gene ID
3383
UniProt
P05362
Accession Number
NP_000192.2
Accession Number mRNA
NM_000201
Chromosomal Location
19p13.3-p13.2
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Recombinant human ICAM1 N-terminal protein
Clone
(#7D22)
Applications
ELISA, WB, IHC (Formalin/P)
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Bioactivity
WB: 1:100-1000; IHC (Formalin/Paraffin) : 1:25-50; ELISA: Yes
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG1
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