GRO-gamma (CXCL3)
All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant human GRO-γ is a 7.9 kDa protein consisting of 73 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.
Product Specifications
Synonyms
CXCL3; GRO3; GROg; MIP2B; SCYB3; MIP-2b; CINC-2b
NCBI Gene ID
2921
UniProt
P19876
Accession Number
NP_002081.2
Accession Number mRNA
NM_002090.2
Chromosomal Location
4q21
Reactivity
Human
Cross Reactivity
Hamster, Human, Mouse
Sequence
ASVVTELRCQ CLQTLQGIHL KNIQSVNVRS PGPHCAQTEV IATLKNGKKA CLNPASPMVQ KIIEKILNKG STN
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract 293 transfected CXCR2 cells using a concentration range of 10-100 ng/ml.
Length
73
Form
Lyophilized
Molecular Weight
7.9 kDa
Host or Source
E. coli
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