Granzyme B
Granzyme family serine proteases are stored in the granules of cytotoxic T lymphocytes and natural killer cells. Granzymes contain one S1 protease domain and are synthesized as preproproteins. Granzymes are released toward pathogen infected or transformed target cells during cellular immune reactions. Target cell entry by granzymes is through perforin channels. Granzymes trigger apoptosis by caspase-dependent and -independent mechanisms. There are five granzymes (A, B, G, H and K) in human and many more in mouse and rat.
Product Specifications
Synonyms
Gzmb; GZB; CCP1; Ctla1; Ctla-1; AI553453; CCP-1/C11
NCBI Gene ID
14939
UniProt
P10144
Accession Number
NP_004122.2
Accession Number mRNA
NM_004131.4
Chromosomal Location
14 D3; 14 20.5 cM
Reactivity
Mouse
Cross Reactivity
Mouse
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Length
227
Form
Lyophilized
Molecular Weight
28.9 kDa
Host or Source
Insect cells
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