Gp130
Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130. The complex then undergoes homodimerization and signal transduction. For other IL-6 family cytokines, such as LIF and OSM, signal transduction is similarly triggered by the heterodimerization of gp130 with LIFR or OSM R.
Product Specifications
Synonyms
Il6st; CD130; gp130; AA389424; BB405851; D13Ertd699e; 5133400A03Rik
NCBI Gene ID
16195
UniProt
Q00560
Accession Number
NP_034690.3
Accession Number mRNA
NM_010560.3
Chromosomal Location
13 D2.2; 13 67.0 cM
Reactivity
Anti-Mouse
Target Antigen
Recombinant mouse GP130
Clone
(#5R33)
Applications
WB, ICC
Purification Method
Protein G/A chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Rat
Isotype
IgG2
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