What is the catalog number for GDF-2?

The catalog number for GDF-2 is 100-383.

What sizes are available for GDF-2?

GDF-2 is available in the following size(s): 10 µg.

GDF-2 is currently made to order / not held in immediate stock. Contact us for lead time.

GDF-2

GDF-2 belongs to the TGF-ß cytokine family whose members play an important role during prenatal development and postnatal growth, remodeling and maintenance of a variety of tissues and organs. GDF-2 is expressed mainly in nonparenchymal cells of the liver, but is also found in other various cells and tissues. GDF-2 can signal through the ALK1 receptor and has been implicated in a number of physiologic events. These include regulation of the hepatic reticuloendothelial system, glucose homeostasis, and iron homeostasis, as well as the inhibition of angiogenesis. Recombinant human GDF-2 is a 24.1 kDa disulfide linked homodimeric protein consisting of two 110 amino acid polypeptide chains.

Product Specifications

Synonyms

GDF2; BMP9; BMP-9

NCBI Gene ID

2658

UniProt

Q9UK05

Accession Number

NP_057288

Accession Number mRNA

NM_016204

Chromosomal Location

10q11.22

Reactivity

Human

Cross Reactivity

Mouse

Sequence

SAGAGSHCQK TSLRVNFEDI GWDSWIIAPK EYEAYECKGG CFFPLADDVT PTKHAIVQTL VHLKFPTKVG KACCVPTKLS PISVLYKDDM GVPTLKYHYE GMSVAECGCR

Assay Protocol

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Endotoxin

< 0.1 ng/µg of protein (< 1EU/µg)

Purity

> 95% by SDS-PAGE & HPLC analyses

Bioactivity

Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.9 ng/ml.

Length

110

Form

Lyophilized

Reconstitution

Water

Molecular Weight

24.1 kDa

Storage Conditions

The lyophilized protein is stable at room temperature for 1 month and at 4°C for 6 months. Reconstituted working aliquots are stable for 1 week at 2°C to 8°C and for 3 months at -20°C to -80°C.