FRP-1, soluble
Secreted Frizzled Related Proteins (sFRPs) modulate WNT signaling by binding directly to WNT proteins in a manner that affects their receptor binding and signaling capabilities. sFRP-1 is a widely distributed protein that can bind directly to WNT1, WNT2, and possibly other WNT proteins, and generally exerts anti-proliferative effects consistent with activity as a WNT antagonist. It also inhibits apoptosis and has been found to be down-regulated in many solid tumors, but up-regulated in uterine leiomyomas. Recombinant human sFRP-1 is a glycosylated 283 amino acid protein containing a cysteine rich Frizzled homologous domain.
Product Specifications
Synonyms
Soluble Frizzled Related Protein-1, Secreted Apoptosis Related protein-2, SARP-2
NCBI Gene ID
6422
UniProt
Q8N474
Accession Number
NP_003003.3
Accession Number mRNA
NM_003012.4
Chromosomal Location
8p11.21
Reactivity
Human
Cross Reactivity
Mouse
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 97% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to inhibit BMP-2 proliferation effect of ATDC-5 cells. The expected ED50 is 0.3–0.5 μg/ml.
Length
283
Form
Lyophilized
Molecular Weight
32.5 kDa
Host or Source
HeLa cells
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