Flt-3 Ligand
Flt3-ligand (flk2-ligand) stimulates the proliferation and colony formation of certain BM precursor cells including CD34+ cells. Flt3-ligand produced in E. coli is a soluble non-glycosylated 17.6 kDa polypeptide containing 155 amino acid residues which comprises the extracellular domain of the transmembrane flt3-ligand protein.
Product Specifications
Synonyms
FLT3; FLK2; STK1; CD135; FLK-2
NCBI Gene ID
2323
UniProt
P49771
Accession Number
NP_001450.2
Accession Number mRNA
NM_001459.3
Chromosomal Location
19q13.3
Reactivity
Human
Cross Reactivity
Human
Sequence
TQDCSFQHSP ISSDFAVKIR ELSDYLLQDY PVTVASNLQD EELCGGLWRL VLAQRWMERL KTVAGSKMQG LLERVNTEIH FVTKCAFQPP PSCLRFVQTN ISRLLQETSE QLVALKPWIT RQNFSRCLEL QCQPDSSTLP PPWSPRPLEA TAPTA
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & Coomassie stain
Bioactivity
Determined by the dose-dependent stimulation of the proliferation of human AML5 cells. The expected ED50 for this effect is 0,5 – 1 ng/mL.
Length
155
Form
Lyophilized
Molecular Weight
17.6 kDa
Host or Source
E. coli
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