FGF-18

FGF-18 is a heparin binding growth factor that belongs to the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-18 is an essential regulator of long bone and calvarial development. FGF-18 signals through FGFR 1c, 2c, 3c, and 4. Recombinant E.coli derived human FGF-18 is a 20.1 kDa protein consisting of 173 amino acid residues, resulting from c-terminal truncation of the full length protein.

Product Specifications

Synonyms

FGF18; ZFGF5; FGF-18

NCBI Gene ID

8817

UniProt

O76093

Accession Number

NP_003853.1

Accession Number mRNA

NM_003862

Chromosomal Location

5q34

Reactivity

Human

Cross Reactivity

Mouse, Rat, Human

Sequence

AEENVDFRIH VENQTRARDD VSRKQLRLYQ LYSRTSGKHI QVLGRRISAR GEDGDKYAQL LVETDTFGSQ VRIKGKETEF YLCMNRKGKL VGKPDGTSKE CVFIEKVLEN NYTALMSAKY SGWYVGFTKK GRPRKGPKTR ENQQDVHFMK RYPKGQPELQ KPFKYTTVTK RSR

Endotoxin

< 0.1 ng/µg of protein (< 1EU/µg)

Purity

> 95% by SDS-PAGE & HPLC analyses

Bioactivity

The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is ≤ 0.5 ng/ml (≥ 2 x 106 units/mg) .