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Exodus-2 (CCL21)

Exodus-2 is a CC chemokine that signals through the CCR7 receptor. It is expressed in lymph nodes of certain endothelial cells, and in the spleen and appendix. Exodus-2 chemoattracts T and B lymphocytes and inhibits hematopoiesis. Exodus-2 contains six cysteine residues, including the four conserved cysteines present in CC chemokines. Recombinant human Exodus-2 is a 12.2 kDa protein containing 111 amino acid residues.

Product Specifications

Synonyms

CCL21; ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21

NCBI Gene ID

6366

UniProt

O00585

Accession Number

NP_002980

Accession Number mRNA

NM_002989

Chromosomal Location

9p13

Reactivity

Human

Cross Reactivity

Monkey, Mouse, Human, Leech, Pig

Sequence

SDGGAQDCCL KYSQRKIPAK VVRSYRKQEP SLGCSIPAIL FLPRKRSQAE LCADPKELWV QQLMQHLDKT PSPQKPAQGC RKDRGASKTG KKGKGSKGCR KTERSQTPKG P

Endotoxin

< 0.1 ng/µg of protein (< 1EU/µg)

Purity

> 98% by SDS-PAGE & HPLC analyses

Bioactivity

Determined by its ability to chemoattract total lymphocyte population using a concentration range of 10.0-100.0 ng/ml.

Length

111

Form

Lyophilized

Molecular Weight

12.2 kDa

Host or Source

E. coli

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