Epigen
Epigen is an EGF-related polypeptide growth factor that signals through the ErbB receptor-1. It is produced in several tissues, including the testis, liver, heart and in certain tumor cells. Epigen is mitogenic for fibroblasts and epithelial cells. Human Epigen is initially synthesized as a glycosylated 14.7 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a mature soluble sequence. Recombinant human Epigen is a 7.9 kDa monomeric protein, containing 72 amino acid residues, which comprises the EGF homologous portion of the Epigen precursor.
Product Specifications
Synonyms
EPGN; EPG; epigen; PRO9904; ALGV3072
NCBI Gene ID
255324
UniProt
Q6UW88
Accession Number
NP_001257922.1
Accession Number mRNA
NM_001270993.1
Chromosomal Location
4q13.3
Reactivity
Human
Cross Reactivity
Mouse
Sequence
AVTVTPPITA QQADNIEGPI ALKFSHLCLE DHNSYCINGA CAFHHELEKA ICRCFTGYTG ERCEHLTLTS YA
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells. The expected ED50 for this effect is 150-300 ng/ml.
Length
72
Form
Lyophilized
Molecular Weight
7.9 kDa
Host or Source
E. coli
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