Eotaxin-3 (CCL26)
Eotaxin-3 is a CC chemokine that signals through the CCR3 receptor. It is produced by endothelial cells stimulated with IL-4 or IL-13. Eotaxin-3 selectively targets cells expressing CCR3, including eosinophils, basophils, T cells and monocytes. Eotaxin-3 has similar activity to Eotaxin and Eotaxin-2, but the three Eotaxins share only a low degree of sequence homology. Recombinant human Eotaxin-3 is an 8.4 kDa protein containing 71 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Product Specifications
Synonyms
CCL26; IMAC; TSC-1; MIP-4a; SCYA26; MIP-4alpha
NCBI Gene ID
10344
UniProt
Q9Y258
Accession Number
NP_006063
Accession Number mRNA
NM_006072
Chromosomal Location
7q11.23
Reactivity
Human
Cross Reactivity
Human
Sequence
TRGSDISKTC CFQYSHKPLP WTWVRSYEFT SNSCSQRAVI FTTKRGKKVC THPRKKWVQK YISLLKTPKQ L
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human CCR3/HEK 293 cells. The maximum activity was achieved at 2 µg/ml.
Length
71
Form
Lyophilized
Molecular Weight
8.4 kDa
Host or Source
E. coli
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