Eotaxin (CCL11) (Animal Free)
Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-γ-stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and, along with Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung and in allergic reactions. Recombinant Human Eotaxin is an 8.3 kDa protein containing 74 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
Product Specifications
Synonyms
CCL11
NCBI Gene ID
6356
UniProt
P51671
Accession Number
NP_002977.1
Accession Number mRNA
NM_002986.2
Chromosomal Location
17q12
Reactivity
Human
Cross Reactivity
Human
Sequence
GPASVPTTCC FNLANRKIPL QRLESYRRIT SGKCPQKAVI FKTKLAKDIC ADPKKKWVQD SMKYLDQKSP TPKP
Endotoxin
< 0.01 ng/µg of protein (< 0.1 EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Not available.
Length
74
Form
Lyophilized
Molecular Weight
8.3 kDa
Host or Source
E. coli
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