ENA-78 (8-78aa) / (CXCL5)
ENA-78 is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. ENA-78 is a chemo attractant for neutrophils. The murine homolog of ENA-78 is called LIX. Three N-terminal truncated variants of human ENA-78; ENA 5-78, ENA 8-78, ENA 9-78, contain 74, 71, and 70 amino acid residues, respectively, possess increased biological activity. ENA-78 contains the four conserved cysteine residues present in CXC chemokines, and also contains the ‘ELR’ motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. Recombinant human ENA-78 is a 7.8 kDa protein consisting of 71 amino acid residues.
Product Specifications
Synonyms
CXCL5; SCYB5; ENA-78
NCBI Gene ID
6374
UniProt
P42830
Accession Number
NP_002985.1
Accession Number mRNA
NM_002994.3
Chromosomal Location
4q13.3
Reactivity
Human
Cross Reactivity
Human
Sequence
LRELRCVCLQ TTQGVHPKMI SNLQVFAIGP QCSKVEVVAS LKNGKEICLD PEAPFLKKVI QKILDGGNKE N
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human neutrophils using a concentration range of 10.0-100.0 ng/ml
Length
71
Form
Lyophilized
Molecular Weight
7.8 kDa
Host or Source
E. coli
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