DMP-1

Dentin matrix acidic phosphoprotein 1 is a protein that in humans is encoded by the DMP1 gene. DMP1 is an extracellular matrix protein and a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family (other members being DSPP, IBSP, MEPE, and SPP1) . This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional Arg-Gly-Asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes.

Product Specifications

Synonyms

Dentin matrix acidic phosphoprotein 1, DMP-1; Dentin matrix protein 1

NCBI Gene ID

1758

UniProt

Q13316

Accession Number

NP_001073380.1

Accession Number mRNA

NM_001079911.2

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant Human DMP-1

Clone

(#35K29)

Applications

Purification Method

Protein G chromatography

Assay Protocol

Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.