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Dihydrofolate Reductase

Dihydrofolate reductase (DHFR), also called dihydrofolic acid reductase, are enzymes that hydrogenate folic acid to dihydrofolic acid (DHF) and DHF to tetrahydrofolic acid (THF) . These reactions activate the vitamin folic acid and are essential for nucleotide biosynthesis in all living organisms. In humans, DHFR is found in all tissue types. Mutations at the DHFR gene can cause dihydrofolate reductase deficiency, and this megaloblastic anemia.

Product Specifications

Synonyms

Dihydrofolate reductase

NCBI Gene ID

1719

UniProt

P00374

Accession Number

NP_000782.1

Accession Number mRNA

NM_000791.3

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant human Dihydrofolate Reductase

Clone

(#24A8)

Applications

WB, IHC (P), ICC

Purification Method

Protein G chromatography

Assay Protocol

Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.

Host or Source

Mouse

Isotype

IgG2

Frequently Asked Questions

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