CYR61
CYR61 is a member of the CCN family of secreted cysteine rich regulatory proteins. CYR61 induces angiogenesis by stimulating the proliferation, migration, and adhesion of endothelial cells. Cell migration and adhesion are mediated through binding to specific cell surface integrins and to heparin sulfate proteoglycans. Increased expression of CYR61 is associated with several types of cancer, and correlates with the progression and estrogen independence of human breast cancers. Recombinant human CYR61 is a 39.5 kDa protein containing 357 amino acid residues. It is composed of four distinct structural domains (modules) ; the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK) .
Product Specifications
Synonyms
CYR61; CCN1; GIG1; IGFBP10
NCBI Gene ID
3491
UniProt
O00622
Accession Number
NP_001545.2
Accession Number mRNA
NM_001554
Chromosomal Location
1p22.3
Reactivity
Human
Cross Reactivity
Mouse, Human, Chicken
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by the dose-dependent stimulation of the proliferation of murine 3T3 cells. The expected ED50 for this effect is 2.0-3.0 μg/ml
Length
357
Form
Lyophilized
Buffer
10 mM Sodium Citrate, pH 3.0 + 50 mM NaCl
Molecular Weight
39.5 kDa
Host or Source
E. coli
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