CTLA-4
CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA-4 is up-regulated rapidly following T cell activation and CD28 ligation. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28.
Product Specifications
Synonyms
CTLA4; CD; GSE; GRD4; ICOS; CD152; CTLA-4; IDDM12; CELIAC3
NCBI Gene ID
1493
UniProt
P16410
Accession Number
NP_005205.2
Accession Number mRNA
NM_005214.4
Chromosomal Location
2q33
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human recombinant CTLA-4
Clone
(#8F16)
Applications
WB
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG2
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
POLR2F Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)
Rabbit anti-Drosophila melanogaster (Fruit fly) GR10B Polyclonal Antibody