Cripto-1

Cripto, also known as TDGF-1 (Teratocarcinoma-Derived Growth Factor), is the founding member of the Epidermal Growth Factor-Cripto-1/FRL1/Cryptic Protein family of signaling proteins that function in cancer and various developmental processes. Mouse Cripto shares 66% and 34% amino acid identity with human Cripto and zebrafish one-eyed pinhead (OEP), respectively. Genetic evidence from mice and zebrafish points to a role for Cripto as an essential cofactor in Nodal signaling.

Product Specifications

Synonyms

TDGF1; CR; CRGF; CRIPTO

NCBI Gene ID

6997

UniProt

P13385

Accession Number

NP_003203.1

Accession Number mRNA

NM_003212.3

Chromosomal Location

3p21.31

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Human recombinant Cripto-1

Clone

(#6M17)

Applications

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.