Coagulation Factor XI (Light Chain)

Coagulation Factor XI is synthesized in the liver and circulates in the plasma as a disulfide bond-linked dimer complexed with High Molecular Weight Kininogen. Factor XI is converted into active XIa either via the contact phase of blood coagulation or through Thrombin-mediated activation on the platelet surface. The resulting XIa converts Coagulation Factor IX into IXa, which subsequently activates Coagulation Factor X (Xa) . Xa then can mediate Coagulation Factor II/Thrombin activation. Patients with factor XI deficiency are prone to excessive bleeding after hemostatic challenge.

Product Specifications

Synonyms

F11; FXI

NCBI Gene ID

2160

UniProt

P03951

Accession Number

NP_000119.1

Accession Number mRNA

NM_000128.3

Chromosomal Location

4q35

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Human recombinant Coagulation factor XI

Clone

(#7C38)

Applications

WB, N

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.