CNTF
CNTF is a potent neural factor that was originally characterized as a vital factor for the survival of chick ciliary neurons in vitro. CNTF is also important for the survival of other neural cell types including primary sensory neurons, motor neurons, basal forebrain neurons and type 2 astrocytes. CNTF is highly conserved across species and exhibits cross-species bioactivity. Recombinant human CNTF is synthesized as a 199 amino acid polypeptide (22.7 kDa) lacking a hydrophobic N-terminal signal for secretion
Product Specifications
Synonyms
CNTF; HCNTF
NCBI Gene ID
1270
UniProt
P26441
Accession Number
NP_000605
Accession Number mRNA
NM_000614
Chromosomal Location
11q12.2
Reactivity
Human
Cross Reactivity
Hamster, Mouse, Rat, Frog, Human
Sequence
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to stimulate proliferation of human TF-1 cells using an ED50 concentration range of 50-150 ng/ml.
Length
199
Form
Lyophilized
Buffer
5 mM Sodium Phosphate, pH 7.5 + 75 mM NaCl
Molecular Weight
22.7 kDa
Host or Source
E. coli
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