CLEC9a (DNGR-1)

CLEC9A, a group V C-type lectin-like receptor, is located in the “Dectin-1 cluster” of related receptors, which are encoded within the natural killer (NK) -gene complex. Expression of human CLEC9A is highly restricted in peripheral blood, being detected only on BDCA3+ dendritic cells and on a small subset of CD14+CD16- monocytes. CLEC9A is expressed at the cell surface as a glycosylated dimer and can mediate endocytosis, but not phagocytosis. CLEC9A possesses a cytoplasmic immunoreceptor tyrosine-based activation-like motif that can recruit Syk kinase, and it was shown, using receptor chimeras, that this receptor can induce proinflammatory cytokine production.

Product Specifications

Synonyms

C-type lectin domain family 9 member A, CD370

NCBI Gene ID

283420

UniProt

Q6UXN8

Accession Number

NP_997228.1

Accession Number mRNA

NM_207345.3

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant Human CLEC9a

Clone

(#30L2)

Applications

Purification Method

Protein G chromatography

Assay Protocol

Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.