Chemerin
Chemerin is a secreted chemoattractant protein that can signal through the chemokine like receptor-1 (CMKLR1) . It is expressed in various tissues, including white adipose tissue, and circulates in blood as an inactive 143 amino acid precursor protein. Biologically active Chemerin is generated by proteolytic removal of C-terminal residues by several circulating proteases. Chemerin acts as a chemoattractant for cells expressing the CMKLR1 receptor, which includes certain dendritic cells, macrophages, and adipocytes. Recombinant human Chemerin is a 15.6 kDa protein consisting of 135 amino acid residues.
Product Specifications
Synonyms
RARRES2; TIG2; HP10433
NCBI Gene ID
5919
UniProt
Q99969
Accession Number
NP_002880.1
Accession Number mRNA
NM_002889.3
Chromosomal Location
7q36.1
Reactivity
Human
Cross Reactivity
Human
Sequence
ELTEAQRRGL QVALEEFHKH PPVQWAFQET SVESAVDTPF PAGIFVRLEF KLQQTSCRKR DWKKPECKVR PNGRKRKCLA CIKLGSEDKV LGRLVHCPIE TQVLREAEEH QETQCLRVQR AGEDPHSFYF PGQFA
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human immature dendritic cells using a concentration range of 1.0-100 ng/ml.
Length
135
Form
Lyophilized
Molecular Weight
15.6 kDa
Host or Source
E. coli
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