CD105/Endoglin
CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF-ß1 and ß3 with high affinity but not to TGF-ß2.
Product Specifications
Synonyms
Endoglin; END; ORW; HHT1; ORW1; CD105
NCBI Gene ID
2022
UniProt
P17813
Accession Number
NP_000109
Accession Number mRNA
NM_000118
Chromosomal Location
9q33-q34.1
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Cell membrane glycoproteins of lymphoblastic leukemia cells
Clone
(#12J11)
Applications
IHC
Purification Method
Protein G/A chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG1
Frequently Asked Questions
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