CD58
CD58, also known as lymphocyte function-associated antigen (LFA-3) is a cell-bound immunoglobulin superfamily receptor with only one known ligand, CD2. CD58 is widely expressed on human hematopoietic and non-hematopoietic tissues, leukocytes, erythrocytes, endothelial and epithelial cells, and fibroblasts. The engagement of CD58 with CD2 optimizes immune recognition and initiates T cell expansion and activation. These contact activities can occur between helper T cells and antigen-presenting cells and cytolytic effectors and target cells.
Product Specifications
Synonyms
CD58; ag3; LFA3; LFA-3
NCBI Gene ID
965
UniProt
P19256
Accession Number
NP_001770.1
Accession Number mRNA
NM_001779.2
Chromosomal Location
1p13
Reactivity
Anti-Human
Cross Reactivity
Human
Target Antigen
Human recombinant CD585 extracellular domain
Clone
(#8G24)
Applications
https://www.reliatech.de/pub/media/ds/ma/101-M311.pdf
Purification Method
Protein G chromatography
Assay Protocol
Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
PBS
Storage Conditions
Host or Source
Mouse
Isotype
IgG2
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