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CD58

CD58, also known as lymphocyte function-associated antigen (LFA-3) is a cell-bound immunoglobulin superfamily receptor with only one known ligand, CD2. CD58 is widely expressed on human hematopoietic and non-hematopoietic tissues, leukocytes, erythrocytes, endothelial and epithelial cells, and fibroblasts. The engagement of CD58 with CD2 optimizes immune recognition and initiates T cell expansion and activation. These contact activities can occur between helper T cells and antigen-presenting cells and cytolytic effectors and target cells.

Product Specifications

Synonyms

CD58; ag3; LFA3; LFA-3

NCBI Gene ID

965

UniProt

P19256

Accession Number

NP_001770.1

Accession Number mRNA

NM_001779.2

Chromosomal Location

1p13

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Human recombinant CD585 extracellular domain

Clone

(#8G24)

Applications

https://www.reliatech.de/pub/media/ds/ma/101-M311.pdf

Purification Method

Protein G chromatography

Assay Protocol

Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

Host or Source

Mouse

Isotype

IgG2

Frequently Asked Questions

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