Itasetron

Itasetron (DA 6215) is a selective 5-HT3 receptor antagonist. Itasetron improves spatial learning and memory abilities in the aged rat. Itasetron has potent antiemetic properties. Itasetron is used for age-related memory degeneration in rodents[1][2].

Product Specifications

CAS Number

123258-84-4

Product Name Alternative

DA 6215; U98079A

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/itasetron.html

Smiles

O=C1N(C2=CC=CC=C2N1)C(N[C@@H]3C[C@@H]4CC[C@@H](N4C)C3)=O

Molecular Formula

C16H20N4O2

Molecular Weight

300.36

References & Citations

[1]N Pitsikas, et al. Itasetron (DAU 6215) prevents age-related memory deficits in the rat in a multiple choice avoidance task. Eur J Pharmacol. 1996 Sep 12;311 (2-3) :115-9. |[2]L Patoia, et al. Intravenous itasetron: establishing the effective dose range for the prophylactic control of acute emesis in cancer patients undergoing high-dose cisplatin chemotherapy. Clin Oncol (R Coll Radiol) . 1999;11 (2) :99-104.