CD19

B-lymphocyte antigen CD19 is a surface protein of the immunoglobulin superfamily. It binds to the B cell receptor on the cell surface of B cells and lowers the threshold of its activability. Thus, overexpression of CD19 in mice, as well as knockout mice, shows that CD19 affects the signaling threshold of receptors that regulate B lymphocyte selection, activation, and differentiation. At the molecular level, CD19 is involved in the activation of phosphatidylinositol 4,5-bisphosphate 3-kinases (PI3K) . It is glycosylated and phosphorylated. Translated with www.DeepL.com/Translator (free version)

Product Specifications

Synonyms

B-lymphocyte surface antigen B4, Differentiation antigen CD19, T-cell surface antigen Leu-12

NCBI Gene ID

930

UniProt

P15391

Accession Number

NP_001171569.1

Accession Number mRNA

NM_001178098.1

Reactivity

Anti-Human

Cross Reactivity

Human

Target Antigen

Recombinant human CD19

Clone

(#13Q82)

Applications

Purification Method

Protein G chromatography

Assay Protocol

Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

Form

Lyophilized

Buffer

PBS

Reconstitution

PBS

Storage Conditions

Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.