FW1256
Product Specifications
UNSPSC Description
FW1256 is a phenyl analogue and a slow-releasing hydrogen sulfide (H2S) donor. FW1256 inhibits NF-κB activity and induces cell apoptosis. FW1256 exerts potent anti-inflammatory effects and has the potential for cancer and cardiovascular disease treatment[1][2].
Target Antigen
Apoptosis; NF-κB
Type
Reference compound
Related Pathways
Apoptosis;NF-κB
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/fw1256.html
Purity
95.0
Solubility
DMSO : ≥ 250 mg/mL
Smiles
S=P1(OC2=CC=CC=C2N1)C3=CC=CC=C3
Molecular Weight
247.25
References & Citations
[1]Huang CW, et al. A novel slow-releasing hydrogen sulfide donor, FW1256, exerts anti-inflammatory effects in mouse macrophages and in vivo. Pharmacol Res. 2016 Nov;113(Pt A):533-546.|[2]Feng W, et al. Discovery of New H2S Releasing Phosphordithioates and 2,3-Dihydro-2-phenyl-2-sulfanylenebenzo[d][1,3,2]oxazaphospholes with Improved Antiproliferative Activity. J Med Chem. 2015 Aug 27;58(16):6456-80.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-121955/FW1256-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-121955/FW1256-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
117089-08-4
Available Sizes
Curated Selection
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