C-10 (CCL6)
Murine C10 belongs to the CC chemokine family and is expressed in myelopoietic bone marrow cultures when stimulated with GM-CSF, M-CSF, IL-3 or IL-4. It signals primarily through the CCR1 receptor. C10 is chemotactic for B cells, CD4+ T cells, monocytes and NK cells and also exhibits powerful suppressive activity on colony formation by different lineages of hematopoietic progenitors. The C10 contains the four highly conserved cysteine residues present in CC chemokines. The mature protein contains 95 amino acid residues. Recombinant murine C-10 is a 10.7 kDa protein containing 95 amino acid residues.
Product Specifications
Synonyms
Grcc10; PME; ULD; CST6; EPM1; STFB; EPM1A
NCBI Gene ID
14790
UniProt
O35127
Accession Number
NP_038563.1
Accession Number mRNA
NM_013535.1
Chromosomal Location
6 F2; 6 60.22 cM
Reactivity
Mouse
Cross Reactivity
Human, Bacteria
Sequence
GLIQEIEKED RRYNPPIIHQ GFQDTSSDCC FSYATQIPCK RFIYYFPTSG GCIKPGIIFI SRRGTQVCAD PSDRRVQRCL STLKQGPRSG NKVIA
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract Balb/c mouse spleen MNCs using a concentration range of 10-100 ng/ml.
Length
95
Form
Lyophilized
Molecular Weight
10.7 kDa
Host or Source
E. coli
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