BRAK (CXCL14)
Breast and Kidney‐expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP‐2 α and β. Recombinant Murine BRAK (CXCL14) is a 9.4 kDa protein containing 77 amino acid residues.
Product Specifications
Synonyms
Breast and Kidney-expressed chemokine, bolekine, NJAC
NCBI Gene ID
57266
UniProt
Q9WUQ5
Accession Number
NP_062514.2
Accession Number mRNA
NM_019568.2
Reactivity
Mouse
Cross Reactivity
Mouse, Human
Sequence
SKCKCSRKGP KIRYSDVKKL EMKPKYPHCE EKMVIVTTKS MSRYRGQEHC LHPKLQSTKR FIKWYNAWNE KRRVYEE
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses
Bioactivity
Determined by its ability to chemoattract human THP-1 monocytes supplemented with Anti-CXCL14.
Length
77
Form
Lyophilized
Molecular Weight
9.4 kDa
Host or Source
E. coli
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