BMP-13 / CDMP-2 (Animal Free)
BMP-13 is expressed in hypertrophic chondrocytes during embryonic development of long bones. Continued postnatal expression of BMP-13 in articular cartilage suggests that it plays a regulatory role in the growth and maintenance of articular cartilage. Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects. The functional form of BMP-13/CDMP-2 is a disulfide-linked homodimer of two 120 amino-acid polypeptide chains. This 27.5 kDa protein is obtained by proteolytic processing of a biologically inactive precursor protein of 97.7kDa. Recombinant Human BMP-13/CDMP-2 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.
Product Specifications
Synonyms
GDF6; KFM; KFS; KFS1; KFSL; SGM1; BMP13; CDMP2; MCOP4; SCDO4; MCOPCB6
NCBI Gene ID
392255
UniProt
P43028
Accession Number
NP_038554.1
Accession Number mRNA
NM_013526.1
Chromosomal Location
8q22.1
Reactivity
Human
Cross Reactivity
Mouse, Human
Sequence
TAFASRHGKR HGKKSRLRCS KKPLHVNFKE LGWDDWIIAP LEYEAYHCEG VCDFPLRSHL EPTNHAIIQT LMNSMDPGST PPSCCVPTKL TPISILYIDA GNNVVYKQYE DMVVESCGCR
Endotoxin
Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug)
Purity
≥ 95% by SDS-PAGE gel and HPLC analyses.
Bioactivity
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 2.0-3.0 µg/ml.
Length
120
Form
Lyophilized
Molecular Weight
27.0 kDa
Host or Source
E. coli
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