Betacellulin
Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.
Product Specifications
Synonyms
BTC
NCBI Gene ID
685
UniProt
P35070
Accession Number
NP_001720
Accession Number mRNA
NM_001729
Chromosomal Location
4Q13-q21
Reactivity
Human
Cross Reactivity
Mouse, Human
Sequence
DGNSTRSPET NGLLCGDPEE NCAATTTQSK RKGHFSRCPK QYKHYCIKGR CRFVVAEQTP SCVCDEGYIG ARCERVDLFY
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
>98% by SDS-PAGE & HPLC analyses
Bioactivity
Length
80
Form
Lyophilized
Molecular Weight
9.0 kDa
Host or Source
E. coli
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