BCMA
BCMA, a member of the TNF receptor superfamily, binds to BAFF and APRIL. BCMA is expressed on mature B-cells and other B-cell lines and plays an important role in B cell development, function and regulation. BCMA also has the capability to activate NF-kappaB and JNK. The human BCMA gene codes for a 184 amino acid type I transmembrane protein, which contains a 54 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 107 amino acid extracellular domain. Recombinant soluble BCMA is a 50 amino acid polypeptide (5.3 kDa) comprising the TNFR homologous region of the BCMA protein.
Product Specifications
Synonyms
TNFRSF17; BCM; BCMA; CD269
NCBI Gene ID
608
UniProt
Q02223
Accession Number
NP_001183
Accession Number mRNA
NM_001192
Chromosomal Location
16p13.1
Reactivity
Human
Cross Reactivity
Human
Sequence
AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to neutralize APRIL-induced NF-κB activation in HEK293-NF-κB reporter cells transfected with BCMA receptor.
Length
50
Form
Lyophilized
Molecular Weight
5.3 kDa
Host or Source
E. coli
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