BCA-1
BCA-1/BLC, a CXC chemokine, is expressed in the liver, spleen, lymph nodes, appendix and stomach. It exerts its activities through its only receptor CXCR5. BCA-1/BLC is a potent chemoattractant for B lymphocytes and induces weak chemotactic response in T cells and macrophages. It manifests no activity on neutrophils and monocytes. Recombinant murine BLC is a 9.8 kDa protein containing 88 amino acid residues including the four highly conserved cysteine residues present in CXC chemokines.
Product Specifications
Synonyms
Cxcl13; BLC; Angie; BCA-1; BLR1L; ANGIE2; Scyb13; 4631412M08Rik
NCBI Gene ID
55985
UniProt
O55038
Accession Number
NP_061354.1
Accession Number mRNA
NM_018866.2
Chromosomal Location
5 E3; 5
Reactivity
Mouse
Cross Reactivity
Human, Mouse, Leech, Bacteria
Sequence
VLEVYYTSLR CRCVQESSVF IPRRFIDRIQ ILPRGNGCPR KEIIVWKKNK SIVCVDPQAE WIQRMMEVLR KRSSSTLPVP VFKRKIP
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Determined by its ability to chemoattract human B cells using a concentration range of 1.0-10.0 ng/ml.
Length
87
Form
Lyophilized
Molecular Weight
10.3 kDa
Host or Source
E. coli
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